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卢盈颖
特聘副研究员

个人简介:
卢盈颖,特聘副研究员,香港大学医学院细胞生物学博士,主要研究方向为自噬机制在细胞应激及肿瘤生长转移中的作用。

作为第一作者在Autophagy?(IF?=?12)等著名学术期刊发表SCI论文五篇。作为项目负责人承担国家自然科学基金青年基金一项,广东省前沿与关键技术创新专项资金-粤港联合创新项目一项。作为课题组主要成员参与国家自然科学基金面上项目两项,香港创新及科技基金(Innovation?and?Technology?Fund)一项,香港研究资助局(Research?Grants?Council)基金四项。目前获得中国国家专利一项,深圳市科技创新委员会颁发的“省级科技项目奖”一次。目前实验室主要研究新型自噬调控剂的鉴定筛选及其抗肿瘤的分子机制的研究。

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主要发表论文:
1.?Lu,?Y.?Y.,?Dong,?S.?C.,?Hao,?B.?X.,?et?al.?(2014).?Vacuolin-1?Potently?and?Reversibly?Inhibits?Autophagosome-Lysosome?Fusion?by?Activating?RAB5.?Autophagy?10,?1-12.
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2.?Chen,?C.#,?Lu,?Y.?Y.#,?Siu,?H.?M.#,?Guan,?J.?T.,?et?al.,?(2017).?Identification?of?Novel?Vacuolin-1?Analogues?as?Autophagy?Inhibitors?by?Virtual?Drug?Screening?and?Chemical?Synthesis.?Molecules?22?(6)?e891.?(#?equal?contribution)
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3.?Wei,?W.?J.,?Lu,?Y.?Y.,?Hao,?B.?X.,?Zhang,?K.?H.,?et?al.,?(2015)?CD38?Is?Required?for?Neural?Differentiation?of?Mouse?Embryonic?Stem?Cells?by?Modulating?Reactive?Oxygen?Species.?Stem?Cell?33(9):?2664-73.
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4.?Hao,?B.?X.,?Lu,?Y.?Y.,?Wang?Q.,?et?al.?(2014).?Role?of?STIM1?in?survival?and?neural?differentiation?of?mouse?embryonic?stem?cells?independent?of?Orai1-mediated?Ca2+?entry.?Stem?Cell?Res.?12,?452-466.
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5.?Zhang,?Z.?H.,?Lu,?Y.?Y.,?Yue,?J.?B.?(2013).?Two?Pore?Channel?2?(TPC2)?differentially?modulates?neural?differentiation?of?mouse?embryonic?stem?cells.?PLoS?ONE?8,?e66077.
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6.?Lu,?Y.?Y.,?Chen,?T.?S.,?Wang,?X.?P.,?Qu,?J.?L.?(2010).?The?JNK?inhibitor?SP600125?enhances?dihydroartemisinin-induced?apoptosis?by?accelerating?Bax?translocation?into?mitochondria?in?human?lung?adenocarcinoma?cells.?FEBS?Lett.?584,?4019-4026.
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7.?Lu,?Y.?Y.,?Chen,?T.?S.,?Wang,?X.?P.,?Li,?L.?(2010).?Single?cell?analysis?of?dihydroartemisinin?(DHA)-induced?apoptosis?through?reactive?oxygen?species?(ROS)-mediated?caspase-8?activation?and?mitochondrial?pathway?in?ASTC-a-1?cells?using?fluorescence?imaging?techniques.?J.?Biomed.?Opt.?15,?046028-1-16.
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8.?Lu,?Y.?Y.,?Chen,?T.?S.,?Qu,?J.?L.,?Pan,?W.?L.,?et?al.?(2009).?Dihydroartemisinin?(DHA)?induces?caspase-3-dependent?apoptosis?in?human?lung?adenocarcinoma?cells.?J.?Biomed.?Sci.?16,?1-16.?
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9.?Chen,?M.,?Lu,?Y.?Y.,?Chen,?T.?S.,?Qu,?J.?L.?(2010).?Confocal?imaging?of?Bim?translocation?to?endoplasmic?reticulum?during?DHA-induced?ASTC-a-1?cell?apoptosis.?Chin.?Optics?Lett.?8,?1-3.

出诊信息
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